alienation

他的冷漠态度导致了朋友的疏远。

His indifference caused the ___alienation of his friends.

由于债务问题，他不得不将房子的所有权转让给银行。

Due to debt issues, he had to complete the ___alienation of his house to the bank.

长期在家工作让他感到与社会疏离。

Working from home for too long made him feel a sense of ___alienation from society.