anguish|anguished|anguishing

他因无法挽救病人而陷入极度的痛苦中。

He was overcome with ___anguish after failing to save the patient.

失去爱人的消息让他陷入极度的痛苦中。

The news of losing his loved one ___anguished him deeply.

等待手术结果的几小时是最令人煎熬的时刻。

The hours waiting for the surgery results were the most ___anguishing time.