estranged

她刻薄的言辞最终疏远了她的朋友们。

Her harsh words eventually ___estranged her from her friends.

多年的误解使他们父女关系疏远。

Years of misunderstanding left the father and daughter ___estranged.

尽管他们已经分居多年，但她仍然关心她的分居丈夫。

Though they've been living apart for years, she still cares about her ___estranged husband.