Taking care of his sick family member for years made him feel walled-in.

walled-in 是由 wall（墙）和 in（在里面）组成的复合形容词，字面意思是"被墙围住的"，比喻"被限制、封闭"的感觉。这里形容长期照顾病人导致的心理压抑状态，就像被无形的墙围住一样无法自由活动。