vicissitude

她经历了人生的起伏，从富裕到贫困，但她始终没有放弃。

She endured the ___vicissitudes of life, from wealth to poverty, but never gave up.

科技股市的突然动荡一夜之间蒸发了他一半的退休储蓄。

The sudden ___vicissitudes of the tech stock market wiped out half of his retirement savings overnight.

她将失去公司工作这一人生变故视为自己开面包店的机会。

She viewed the ___vicissitude of losing her corporate job as an opportunity to start her own bakery.