deranged

长期失眠会扰乱她的思维。

Chronic insomnia has ___deranged her thought process.

持续的战争景象最终使他精神错乱。

The constant images of war eventually ___deranged him.

孩子们的吵闹完全打乱了我们的会议安排。

The kids' noise completely ___deranged our meeting schedule.