长期酗酒会导致严重的健康问题。

Chronic ___alcoholism can lead to serious health problems.

他的酗酒问题严重影响了他的家庭关系。

His ___alcoholism severely affected his family relationships.

他的酗酒问题严重影响了他的工作和家庭生活。

His ___alcoholism seriously affected both his work and family life.