Working from home during the pandemic gave me a feeling of isolation.

isolation 是名词，来自动词 isolate（隔离、孤立）。词根 "isol" 源自拉丁语 "insula"（岛屿），加上后缀 "-ation" 表示状态或行为。isolation 字面意思是"像岛屿一样被隔开的状态"，引申为"隔离、孤独感"。