instructions

这份说明书被揉皱了。

The ___instructions are crumpled.

使用设备前请仔细阅读说明。

Please read the ___instructions carefully before using the device.

医生给了病人详细的服药指导。

The doctor gave the patient specific ___instructions on how to take the medicine.

我的新工作需要我遵循很多指示。

My new job requires me to follow many ___instructions.