profound

他的离世给她带来了深切的悲伤。

His death left her with a ___profound sense of sadness.

社交媒体对社会产生了深远的影响。

Social media has had a ___profound ___impact on society.

他的演讲对听众产生了深远的影响。

His speech had ___a ___profound ___effect on the audience.