长时间的等待让他感到非常烦躁。

The long wait filled him with ___irritation.

长时间戴隐形眼镜可能会导致眼睛不适。

Wearing contact lenses for too long can cause eye ___irritation.

蚊子的嗡嗡声真是一种令人烦躁的干扰。

The buzzing of mosquitoes is a constant ___irritation when trying to sleep.