despair

她充满了深深的绝望感。

She was filled with a deep sense of ___despair.

他们因失去的钱财而陷入绝望的深渊。

They're in the depths of ___despair over the money they've lost.

当我们所有的计划都落空时，我们陷入了绝望的深渊。

When all our plans fell through, we were left in the depths of ___despair.