The virulence in his remarks was so evident that it made all listeners uncomfortable.

virulence 是名词，来自形容词 virulent（恶毒的、剧毒的）。词根 vir- 来自拉丁语 virus（毒液），后缀 -ulence 表示性质或状态。virulence 指"毒性"或"恶意"，形容言语或行为带有强烈的伤害性。