失去至亲的痛楚让他陷入了极度的精神折磨。

The loss of his loved one left him in unbearable ___agony.

听到这个坏消息，他陷入了深深的痛苦之中。

He was in ___agony after hearing the terrible news.

他在马拉松的最后几公里经历了极度的痛苦。

He went through the ___agony of the last few kilometers in the marathon.