aggravation

他的唠叨真是让人烦躁。

His nagging is giving me a lot of ___aggravation.

持续的下雨加重了她的关节炎疼痛。

The constant rain caused an ___aggravation of her arthritis pain.

她的抱怨只会加剧问题的严重性。

Her complaints only caused further ___aggravation to the problem.