consequence

这个问题后果重大，需要我们认真考虑。

This issue is of great ___consequence and requires our careful consideration.

熬夜的后果是第二天早上起不来床。

Staying up late has the ___consequence of not being able to get out of bed the next morning.

他长期的压力是工作过度的一个必然结果。

His constant stress was a natural ___consequence of overworking.