loneliness

他对独自生活的深深孤独毫无准备。

He wasn't prepared for the profound ___loneliness of living alone.

长期的孤独可能导致严重的心理健康问题。

Prolonged ___loneliness can lead to significant mental health issues.

我没有为生活在小村庄的孤独做好准备。

I wasn't prepared for the ___loneliness of living in a small village.