His unique sense of humor distinguishes him among his friends.

distinguishes 是动词 distinguish 的第三人称单数形式。distinguish 由前缀 dis-（表示"分开"）和词根 stinguere（拉丁语，意为"刺、戳"）组成，原意是"通过标记来区分"。在现代英语中表示"使与众不同、区分"的意思。