devastating

她毁灭性的评论让他感到非常沮丧。

Her ___devastating comments left him feeling deeply upset.

尽管消息令人震惊，但没有人放弃希望。

Despite the ___devastating news, no one is giving up hope.

这场火灾对当地野生动物造成了毁灭性的影响。

The fire has had a ___devastating effect on the local wildlife.