这个历史遗址对当地文化有着深远的意义。

This historical site holds great ___significance for the local culture.

这幅画背后隐藏着深刻的象征意义。

The painting carries deep ___significance behind its imagery.

实验结果表明这种药物的治疗效果具有统计学意义。

The test results showed statistical ___significance in the drug's therapeutic effect.