失去工作后，经济困难成了他们全家的巨大磨难。

After losing his job, financial hardship became a major tribulation for his whole family.

tribulation 来自拉丁语 tribulare（压榨、折磨），指"磨难、苦难"。这个词常用来形容长期或严重的困难，带有精神或情感上的痛苦意味。