她经历了那次分手后整个人都崩溃了，整天把自己关在房间里。

After that breakup, she became totally ___screwed-up and locked herself in the room all day.

我的电脑系统完全搞砸了，现在连开机都困难。

My computer system is completely ___screwed up and now it can't even boot properly.

我的旅行计划全被打乱了，因为航班时刻表搞混了。

My travel plans got totally ___screwed up because the flight schedule was messed up.