detriment

他过度工作，损害了健康。

He worked excessively to the ___detriment of his health.

过度使用手机会对你的视力造成损害。

Excessive phone use can be a ___detriment to your eyesight.

熬夜对健康有很大的危害。

Staying up late is a significant ___detriment to your well-being.